PHOSPHONIC ACID AND PHOSPHINIC ACID TRIPEPTIDES AS INHIBITORS OF GLUTATHIONYLSPERMIDINE SYNTHETASE

Authors
VERBRUGGEN C DECRAECKER S RAJAN P JIAO XY BORLOO M SMITH K FAIRLAMB AH HAEMERS A
Citation
C. Verbruggen et al., PHOSPHONIC ACID AND PHOSPHINIC ACID TRIPEPTIDES AS INHIBITORS OF GLUTATHIONYLSPERMIDINE SYNTHETASE, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 253-258
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
3
Year of publication
1996
Pages
253 - 258
Database
ISI
SICI code
0960-894X(1996)6:3<253:PAAPAT>2.0.ZU;2-Z
Abstract
A series of phosphonic and phosphinic acid derivatives of glutathione were synthesized as potential inhibitors of glutathionylspermidine syn thetase, an essential enzyme in the biosynthesis of trypanothione in t rypanosomatids. The compounds showed moderate activity.