SYNTHESIS AND ANALGESIC ACTIVITY OF EPIBATIDINE ANALOGS

Authors
XU R BAI DL CHU GH TAO JN ZHU XZ
Citation
R. Xu et al., SYNTHESIS AND ANALGESIC ACTIVITY OF EPIBATIDINE ANALOGS, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 279-282
Citations number
28
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
3
Year of publication
1996
Pages
279 - 282
Database
ISI
SICI code
0960-894X(1996)6:3<279:SAAAOE>2.0.ZU;2-M
Abstract
Two epibatidine analogues with different skeleton were synthesized and their analgesic activity was evaluated. Compound 2 which has the 8-az abicyclo[3.2.1]octane ring system showed potent analgesic activity in hot-plate assay.