INHIBITION OF MATRIX METALLOPROTEINASES BY P-1 SUBSTITUTED N-CARBOXYALKYL DIPEPTIDES

Authors
CHAPMAN KT WALES J SAHOO SP NIEDZWIECKI LM IZQUIERDOMARTIN M CHANG BC HARRISON RK STEIN RL HAGMANN WK
Citation
Kt. Chapman et al., INHIBITION OF MATRIX METALLOPROTEINASES BY P-1 SUBSTITUTED N-CARBOXYALKYL DIPEPTIDES, Bioorganic & medicinal chemistry letters, 6(3), 1996, pp. 329-332
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
6
Issue
3
Year of publication
1996
Pages
329 - 332
Database
ISI
SICI code
0960-894X(1996)6:3<329:IOMMBP>2.0.ZU;2-A
Abstract
Aroyl and arylacyl aminoalkyl substitutents at the P-1 position of N-c arboxyalkyl dipeptides were found to enhance potency and selectivity f or stromelysin-1 (MMP-3). In particular, the phthalimidobutyl and phen ylpropanoylaminopropyl groups offered inhibitors of MMP-3 with K-i's o f similar to 10 nM.