We studied a cohort of 73 children exposed to cocaine in utero to char
acterize the spectrum of neurologic and ophthalmologic abnormalities;
36 children with no documented in utero drug exposure were selected as
a control group. Most referrals of cocaine-exposed children to the ch
ild neurologist were made in the 1st year of life (81%). Reasons for r
eferral were hypertonia (29%), seizures (22%), developmental delay (11
%), tremulousness (11%), and hypotonia (4%). The most common abnormal
finding in the cocaine-exposed children was hypertonia/hyperreflexia (
63%), which was rarely seen in the control group. In addition, hyperto
nia/hyperreflexia was underdiagnosed by referring physicians. Similarl
y, hypotonia was seen on neurologic examination of cocaine-exposed chi
ldren more frequently than documented by referral (16% versus 4%). Hyp
otonia was rarely seen in the control group. Twelve (43%) of 28 cocain
e-exposed children seen by a pediatric ophthalmologist had structural
ophthalmologic abnormalities. Neurologic and ophthalmologic findings s
uggesting structural lesions of the nervous system must be considered
in cocaine-exposed children.