ISOLATION OF LEISHMANICIDAL TRITERPENES AND LIGNANS FROM THE AMAZONIAN LIANA DOLIOCARPUS-DENTATUS (DILLENIACEAE)

Authors
SAUVAIN M KUNESCH N POISSON J GANTIER JC GAYRAL P DEDET JP
Citation
M. Sauvain et al., ISOLATION OF LEISHMANICIDAL TRITERPENES AND LIGNANS FROM THE AMAZONIAN LIANA DOLIOCARPUS-DENTATUS (DILLENIACEAE), PTR. Phytotherapy research, 10(1), 1996, pp. 1-4
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
10
Issue
1
Year of publication
1996
Pages
1 - 4
Database
ISI
SICI code
0951-418X(1996)10:1<1:IOLTAL>2.0.ZU;2-#
Abstract
The in vitro antileishmanial activity of triterpenes and Lignans of an Amazonian medicinal plant, Doliocarpus dentatus (Aublet) Standley, is reported for the first time against amastigotes of Leishmania amazone nsis. Terpenes, for example, betulinic acid, betulin and betulinaldehy de were isolated by bioassay-linked extraction. The lignans were chara cterized as (+) pinoresinol, (+) medioresinol and (-) lirioresinol B.