ACTION OF PLUCHEA-INDICA METHANOL EXTRACT AS A DUAL INHIBITOR ON PAF-INDUCED PAW EDEMA AND GASTRIC DAMAGE

Authors
SEN T GHOSH TK BHATTACHARJEE S CHAUDHURI AKN
Citation
T. Sen et al., ACTION OF PLUCHEA-INDICA METHANOL EXTRACT AS A DUAL INHIBITOR ON PAF-INDUCED PAW EDEMA AND GASTRIC DAMAGE, PTR. Phytotherapy research, 10(1), 1996, pp. 74-76
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
10
Issue
1
Year of publication
1996
Pages
74 - 76
Database
ISI
SICI code
0951-418X(1996)10:1<74:AOPMEA>2.0.ZU;2-3
Abstract
The effect of the methanol fraction of Pluchea indica (P. indica) and certain standard drugs were evaluated on platelet activation factor (P AF)-induced inflammation, gastric necrosis, ulceration and haematologi cal picture. Administration of PAF (i.v.) for 20 min produced signific ant alteration in haematological profiles, considerable inflammation, severe gastric mucosal vasocongestion, necrosis and ulceration. Pretre atment with either P. indica and certain standard drugs significantly inhibited inflammation and incidences of lowered gastric damage.