FLUCONAZOLE-INDUCED CONGENITAL-ANOMALIES IN 3 INFANTS

Fluconazole has been associated with various teratisms in animals, inc luding craniofacial ossification defects, thin, wavy ribs, and renal p elvis defects. We describe three infants born to women who were receiv ing fluconazole through or beyond the first trimester of pregnancy. Al l of the infants had congenital anomalies; no other drug was implicate d. Only one of the three infants survived. Their anomalies, similar to those observed in animal studies, were largely craniofacial, skeletal (i.e., thin, wavy ribs and ossification defects), and cardiac. One of these infants was previously reported as having Antley-Bixler syndrom e; however, given the chronology described herein and the similarity o f this infant to the others, we conclude that her deformities also rep resent the potent teratogenic effect of fluconazole.