Streptococcal toxic shock syndrome (strepTSS) has been associated with
various streptococcal soft-tissue infections including cellulitis, ne
crotizing fasciitis, and peritonitis in adults. We describe a 40-year-
old patient with pharyngitis and strepTSS. Throat swab cultures yielde
d a strain of Streptococcus pyogenes that produced large amounts of er
ythrogenic toxin A. Fluorescence-activated cell sorter analysis of the
patient's peripheral blood lymphocytes revealed generally enhanced ex
pression of the T cell activity markers CD25 and human leukocyte antig
en-DR and a marked increase in the number of gamma delta T cells, larg
ely of the V delta 1-bearing subpopulation. Two more analyses, which w
ere performed 2 weeks and 9 months later, respectively, documented the
course of normalization after the acute episode of strepTSS. The T ce
lls of this patient were stimulated in vitro with supernatants of his
streptococcal isolate, and they proliferated in a dose-dependent manne
r. These proliferating T cells were mainly alpha beta T cells.