ATOM LEVEL ELECTROTOPOLOGICAL STATE INDEXES IN QSAR - DESIGNING AND TESTING ANTITHYROID AGENTS

Purpose. To design new antithyroid agents with less side effects, the electrotopological-state (E-state) indexes of thiourylene moiety (S-N& S) was utilized as a guideline to develop five acyclic thiourylene-typ e compounds with reduced antioxidant property. Methods. These agents w ere synthesized and screened for antithyroid activity in rats using I- 125-thiocyanate discharge technique. In addition, chemiluminescence st udies on the activated polymorphonuclear leukocytes (PMNLs) were also conducted to reveal antioxidant properties of the tested compounds. Re sults. A linear relationship between the in vitro literature value of the formation constants of thiourylene-type compounds with iodine (K-c ) and the S-N&S was observed and utilized in designing those agents. A t least one of the compounds (abouthiouzine) was found to have a poten tial value as an antithyroid agent. The relative efficacy of abouthiou zine [1-n-butyl-3(isonicotinamido)-2-thiourea], after equimolar dose, was 102% and 51.5% of that of propylthiouracil with respect to the rat e of I-125-discharge and I-125-uptake, respectively. In addition, Chem iluminescence studies on PMNLs revealed that abouthiouzine has slight oxidant property. Such properties may provide advantages in avoiding t he iatrogenic hypothyroidism and antithyroid-induced immunological rea ctions. Conclusions. The E-state approach provides guidelines to econo mize efforts and cost of designing new antithyroid drugs.