COMPARISON OF HEPATOTOXICITY OF 1,2-DIBROMOBENZENES, 1,3-DIBROMOBENZENES AND 1,4-DIBROMOBENZENES - THE DYNAMICS OF CHANGES OF SELECTED PARAMETERS OF LIVER NECROSIS IN ACUTE-POISONING IN MICE

Various doses of dibromobenzene isomers (1,2-dBB, 1,3-dBB, 1,4-dBB) we re administered (i.p.) to BALE mice, The levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the liver, and glutamate-pyruvate transaminase (GPT) (EC,2,6,1,2) gamma-glutamyltransferase (gamma-GT) ( EC,2,3,2,2) and triglycerides (TG) in the serum were estimated, A cons iderable decrease of GSH was observed between 2 and 12 h after adminis tration of the compounds. Increases in serum GPT activity (up to 100-f old) and gamma-GT (three-to fivefold) were observed after treatment us ing 1,2- and 1,3-dibromobenzenes; TG decreased in concentration initia lly and then slightly increased. Histopathological examination confirm ed the strong necrotic effect of 1,2- and 1,3-dBB isomers. No such cha nges (elevation of serum GPT activity and necrosis) were noticed after 1 beta-dBB.