RENAL AND SPERMATOZOAL TOXICITY OF ALPHA-BROMOHYDRIN, 3-BROMOLACTATE AND 3-BROMOPYRUVATE

(RS)- and (R)-3-Bromopropan-1,2-diol (alpha-bromohydrin) produced diur esis and glucosuria when administered to male rats but had no effect o n the metabolic activity of rat kidney tubules in vitro. The olridatio n products (RS)-3-bromolactate and 3-bromopyruvate produced brief phas es of diuresis but not glucosuria, and severely inhibited the metaboli c activity of rat kidney tubules in vitro, alpha-Bromohydrin had no ef fect on the metabolic activity of boar spermatozoa whereas the oxidati on products severely affected mitochondrial metabolism, 3-Bromopyruvat e also inhibited boar spermatozoal glyceraldehyde 3-phosphate dehydrog enase.