ON THE MECHANISM BY WHICH 6-KETOCHOLESTANOL PROTECTS MITOCHONDRIA AGAINST UNCOUPLING-INDUCED CA2+ EFFLUX

Authors
CHAVEZ E MORENOSANCHEZ R ZAZUETA C CUELLAR A RAMIREZ J REYESVIVAS H BRAVO C RODRIGUEZENRIQUEZ S
Citation
E. Chavez et al., ON THE MECHANISM BY WHICH 6-KETOCHOLESTANOL PROTECTS MITOCHONDRIA AGAINST UNCOUPLING-INDUCED CA2+ EFFLUX, FEBS letters, 379(3), 1996, pp. 305-308
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
379
Issue
3
Year of publication
1996
Pages
305 - 308
Database
ISI
SICI code
0014-5793(1996)379:3<305:OTMBW6>2.0.ZU;2-7
Abstract
This work shows that 6-ketocholestanol (kCh) inhibits the effect of ca rbonyl cyanide-m-chlorophenyl hydrazone (CCP) on mitochondrial Ca2+ ef flux. Such an effect proved to be caused by diminution of membrane flu idity, therefore, it is affected by the incubation temperature. Furthe rmore, kCh reversed CCP-induced Ca2+ efflux depending on the accumulat ion of phosphate, It is also shown that kCh enhances the effect of car boxyatractyloside on membrane permeability transition.