HISTOLOGICAL AND ELECTRON-MICROSCOPIC OBSERVATIONS ON THE MUCOSA OF PEDICULATE GASTRIC WALL GRAFT TRANSPLANTED TO THE INTESTINES IN WISTAR RATS

Objective. To study the machanism of the development of intestinal met aplasia through the transplantation of a flap of gastric wall with vas cular pedicle to the intestines. Methods. The pedicled gastric wall fl aps of Wistar rats were transplanted to their duodenum, jejunum and co lon respectively. After the operation the rats were killed at the 3th, 6th, 9th and 12th month respectively, and histological change of the gastric grafts was observed with optical and electron microscopy.Resul ts. Intestinal metaplasia was found in all the gastric grafts transpla nted to the intestines and the alkaline phosphatase positive intestina l metaplasia was seen in the gastric graft mucosa transplanted to the duodenum and jejunum. Conclusions. The formation of intestinal metapla sia in the gastric mucosa may be related to a change of the microenvir onment around the tissues, and gastric mucosa may differentiate into i ntestinal mucosa by the increase of pH value. The possible mechanism o f the development of intestinal metaplasia was discussed.