APPLICATIONS OF PRESSURE-TUNING VIBRATIONAL SPECTROSCOPY FROM FUNDAMENTAL MOLECULAR-SPECTROSCOPY TO BIOMEDICAL-RESEARCH

The efforts in our vibrational spectroscopic studies have been focused on the application of pressure-tuning infrared and Raman spectroscopy to the study of structural and dynamic properties in both simple and complex molecular systems in their crystalline state, amorphous state, liquid state and in solutions including aqueous solutions. We have al so applied the pressure-tuning vibrational spectroscopy to test variou s theories in fundamental vibrational spectroscopy such as the Fermi r esonance interactions in the Raman 12 spectra of polymethylene chain s ystems and disorder allowed spectral features in molecular crystals. T he advances in the pressure-tuning infrared spectroscopy for intact bi ological tissues and whole cells in our laboratory allowed us to inves tigate the molecular basis of a wide range of biological and biomedica l problems. In the present review, examples of the complex molecular s ystems are given to demonstrate the potential of the pressure-tuning v ibrational spectroscopy as a powerful tool for the studies of physical and chemical problems ranging form fundamental vibrational spectrosco py to structural changes at the molecular level in human cancers.