DETERMINATION OF ACYCLOVIR (ZOVIRAX) AND GUANINE BY MICROBORE HIGHPERFORMANCE LIQUID-CHROMATOGRAPHY WITH CONFIRMATION BY ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY

Authors
KOURANYLEFOLL E CYR TD
Citation
E. Kouranylefoll et Td. Cyr, DETERMINATION OF ACYCLOVIR (ZOVIRAX) AND GUANINE BY MICROBORE HIGHPERFORMANCE LIQUID-CHROMATOGRAPHY WITH CONFIRMATION BY ATMOSPHERIC-PRESSURE CHEMICAL-IONIZATION MASS-SPECTROMETRY, Canadian journal of applied spectroscopy, 40(6), 1995, pp. 155-159
Citations number
17
Categorie Soggetti
Spectroscopy
Journal title
Canadian journal of applied spectroscopy → ACNP
ISSN journal
11837306
Volume
40
Issue
6
Year of publication
1995
Pages
155 - 159
Database
ISI
SICI code
1183-7306(1995)40:6<155:DOA(AG>2.0.ZU;2-W
Abstract
A microbore high-pertormance liquid chromatography (HPLC) method for t he determination of acyclovir related compounds in drug raw materials, capsules and injectables is described. The total amount of related co mpounds did not exceed 0.72% in all test samples analysed by HPLC-UV. On-line coupling with mass spectrometric detection (atmospheric-pressu re chemical ionization, APCI) was used to confirm that the parent comp ound corresponded to the principal peak in the chromatogram, and the m ajor impurity present at levels of about 0.25-0.40% was identified as guanine.