EXPERIMENTALLY DESIGNED OPTIMIZATION OF DIRECT COMPRESSION TABLETS

The work reported here describes The improvement of an industrial prod uction of tablets formed by direct compression. This formulation conta ined 50% active substance of plant origin as a nonhygroscopic powder. The first step was to evaluate a number of direct compression excipien ts in preformulation tests and then make up a basic formulation provid ing tablets with correct characteristics. The second step was the opti mization of the initial formulation using a two-level factorial experi mental design. This enabled the best formulations to be selected objec tively.