INFLUENCE OF ELECTRICAL FACTORS ON IN-VITRO IONTOPHORETIC DELIVERY OFTIMOLOL MALEATE

The in vitro iontophoretic delivery of timolol maleate (TM) was carrie d out using a modified two-chambered, horizontal diffusion cell. The e ffect of various electrical factors on iontophoretic permeation of dru g was analyzed. The iontophoretic permeation of TM through human cadav er skin was more greatly enhanced than the passive permeation. The inc rease in current intensity linearly increased the permeation of drug. The sine wave form showed the highest permeation than other waveforms used. Pulsed mode iontophoresis seems to be more efficient than consta nt current drug permeation through skin.