EFFECT OF TEMPERATURE ON CHARACTERISTICS OF HYDROXYPROPYLCELLULOSE TABLETS PREPARED BY WET GRANULATION METHODS

In this work, we will study the effect of temperature (35-45 degrees C ) on the disintegration and dissolution rate of theophylline from the tablets containing hydroxypropylcellulose as a binder (binder in solut ion). The results showed that in all cases the increase of the tempera ture led to the acceleration of the disintegration and the dissolution rate of theophylline tablets except in basic formula. The disintegrat ion and dissolution times decrease gradually, then abruptly fall in ti me at the demixing temperature and take the same rime as the basic for mula. It was also observed that the demixing temperature varies with t he concentration of the polymer in the tablet formulation and shows no change in rheological formulation.