To evaluate the sensitivity of a non-receiver-operating characteristic
(ROC) study in assessing small differences of perceived image quality
of hand images acquired by computed radiography (CR) and conventional
screen-film systems, hand images were acquired on 12 patients with bo
th conventional screen-film and CR. Each CR image was then processed w
ith three different edge-enhancement algorithms. One conventional film
and four CR images were then viewed side by side by five radiologists
. Observers rated perceived image quality of each radiograph using a 1
0-category discrete scale. The study was repeated after 6 weeks using
a different block randomization scheme. Despite the small sample size,
significant differences (P < .05) in assigned image quality were dete
cted among CR images acquired at low, medium, and high resolutions. Im
age processing routines did not fully compensate for differences in qu
ality between conventional film and CR-acquired images. The quality ra
ting of the reference conventional image was found to be dependent on
the quality of images with which it was compared. Small, highly sensit
ive study designs can be used to identify radiologists' perceived diff
erences in image quality. ''Reference'' or ''gold standard'' quality a
re important in such studies. Edge-enhancement schemes cannot fully co
mpensate for perceived image quality degradations because of reduced i
mage resolution. Copyright (C) 1996 by W.B. Saunders Company