A total of 142 crossbred beef steers were included in a study of the e
ffect of Fasciola hepatica on productivity. A bistadial study was desi
gned which consisted of a grazing phase and a feedlot phase. The grazi
ng phase was designed to use induced subclinical liver fluke infection
s in beef steers to determine the influence of immature liver flukes (
up to 10 weeks post-infection) on beef production while animals are on
pasture. Upon subsequent entry into the feeding phase, the objective
was to evaluate the effect of treating fluke-infected steers with an i
vermectin/clorsulon combination or ivermectin alone in terms of perfor
mance and on hematological values. This trial demonstrated the benefit
of treating liver fluke-infected feeder cattle with ivermectin/clorsu
lon at entry into the feedlot even though all liver flukes were not ad
ults at the time of treatment and the fluke infection level was subcli
nical. Economic benefit can be anticipated in feeder cattle if natural
infections are similar to the artificial infection used in this field
study.