CHAIN MIGRATION OF NEURONAL PRECURSORS

Citation
C. Lois et al., CHAIN MIGRATION OF NEURONAL PRECURSORS, Science, 271(5251), 1996, pp. 978-981
Citations number
48
Categorie Soggetti
Multidisciplinary Sciences
Journal title
ISSN journal
00368075
Volume
271
Issue
5251
Year of publication
1996
Pages
978 - 981
Database
ISI
SICI code
0036-8075(1996)271:5251<978:CMONP>2.0.ZU;2-E
Abstract
In the brain of adult mice, cells that divide in the subventricular zo ne of the lateral ventricle migrate up to 5 millimeters to the olfacto ry bulb where they differentiate into neurons. These migrating cells w ere found to move as chains through a well-defined pathway, the rostra l migratory stream. Electron microscopic analysis of serial sections s howed that these chains contained only closely apposed, elongated neur oblasts connected by membrane specializations. A second cell type, whi ch contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursor s moved associated with each other and were not guided by radial glial or axonal fibers.