Three liver transplant patients developed serious intraabdominal infec
tions and recurrent bacteremias due to strains of Enterococcus faecium
with high-level resistance to vancomycin. The enterococci were also r
esistant to all other antibacterials except pristinamycin, which, give
n orally, proved ineffective. One strain was sensitive to tetracycline
. Increasingly, clinicians are likely to encounter infections caused b
y multiply-resistant enterococci, and these cases illustrate the serio
usness of such infections in compromised patients.