CDK INHIBITORS IN DEVELOPMENT AND CANCER

Citation
Jw. Harper et Sj. Elledge, CDK INHIBITORS IN DEVELOPMENT AND CANCER, Current opinion in genetics & development, 6(1), 1996, pp. 56-64
Citations number
63
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
ISSN journal
0959437X
Volume
6
Issue
1
Year of publication
1996
Pages
56 - 64
Database
ISI
SICI code
0959-437X(1996)6:1<56:CIIDAC>2.0.ZU;2-0
Abstract
Activation of cyclin-dependent kinases is the primary control point of cell proliferation. Recent advances in the understanding of cell-cycl e regulation have uncovered two families of proteins that bind and inh ibit these kinases. These proteins are likely mediators of development and differentiation, and may provide molecular connections between th e pathways of development and tumorigenesis.