MECHANISMS OF CARCINOGENESIS AND THE MUTANT MOUSE

Authors
WILLIAMS BO JACKS T
Citation
Bo. Williams et T. Jacks, MECHANISMS OF CARCINOGENESIS AND THE MUTANT MOUSE, Current opinion in genetics & development, 6(1), 1996, pp. 65-70
Citations number
71
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
6
Issue
1
Year of publication
1996
Pages
65 - 70
Database
ISI
SICI code
0959-437X(1996)6:1<65:MOCATM>2.0.ZU;2-A
Abstract
Gene targeting in embryonic stem cells has allowed the creation of sev eral new mouse strains carrying mutations in the murine homologs of hu man tumor suppressor genes. The phenotypes of these mutant strains are reviewed. In addition, recent experiments utilizing the Apc(Min) and p53 mutant animals to address specific mechanisms of carcinogenesis ar e discussed.