Authors
Citation
Yf. Mak et Baj. Ponder, RET ONCOGENE, Current opinion in genetics & development, 6(1), 1996, pp. 82-86
Citations number
45
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
ISSN journal
0959437X
Volume
6
Issue
1
Year of publication
1996
Pages
82 - 86
Database
ISI
SICI code
0959-437X(1996)6:1<82:RO>2.0.ZU;2-S
Abstract
RET mutations have been identified as the underlying cause of two cong
enital diseases that predominately affect tissues of neural crest orig
in: the MEN 2 cancer syndromes and a proportion of cases of dominantly
inherited Hirschsprung disease, a disorder of gut development. This r
eview summarizes the disease-causing mutations and our present underst
anding of their possible effects on RET protein function.