NEUROFIBROMATOSIS-2 - LOSS OF MERLIN PROTECTIVE SPELL

Authors
GUSELLA JF RAMESH V MACCOLLIN M JACOBY LB
Citation
Jf. Gusella et al., NEUROFIBROMATOSIS-2 - LOSS OF MERLIN PROTECTIVE SPELL, Current opinion in genetics & development, 6(1), 1996, pp. 87-92
Citations number
68
Categorie Soggetti
Biology,"Cell Biology","Biothechnology & Applied Migrobiology","Genetics & Heredity
Journal title
Current opinion in genetics & development → ACNP
ISSN journal
0959437X
Volume
6
Issue
1
Year of publication
1996
Pages
87 - 92
Database
ISI
SICI code
0959-437X(1996)6:1<87:N-LOMP>2.0.ZU;2-N
Abstract
Schwannomas and meningiomas occur as multiple tumors in sufferers of n eurofibromatosis 2 (NF2) and as solitary tumors in the general populat ion due to the inactivation of a gene at chromosome 22q12. In 1993, a location cloning approach revealed this tumor suppressor, dubbed merli n, as a novel member of a family of proteins that link elements of the cytoskeleton and the cell membrane. Subsequent investigations have co nfirmed merlin's role in tumor formation, but have yet to reveal its m echanism of action.