DIAZEPAM PRETREATMENT ATTENUATES THE SUPPRESSANT EFFECT OF INTRAPERITONEAL ADMINISTRATION OF CHOLECYSTOKININ (CCK) ON FOOD-INTAKE IN FOOD-DEPRIVED RATS

Authors
EBENEZER IS WARREN D
Citation
Is. Ebenezer et D. Warren, DIAZEPAM PRETREATMENT ATTENUATES THE SUPPRESSANT EFFECT OF INTRAPERITONEAL ADMINISTRATION OF CHOLECYSTOKININ (CCK) ON FOOD-INTAKE IN FOOD-DEPRIVED RATS, Methods and findings in experimental and clinical pharmacology, 15(9), 1993, pp. 659-663
Citations number
27
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Methods and findings in experimental and clinical pharmacology → ACNP
ISSN journal
03790355
Volume
15
Issue
9
Year of publication
1993
Pages
659 - 663
Database
ISI
SICI code
0379-0355(1993)15:9<659:DPATSE>2.0.ZU;2-L
Abstract
The aim of the present study was to determine whether diazepam pretrea tment could prevent the inhibitory effect of systemically administered CCK on food intake in rats. Diazepam (0.5 and 1 mg/kg) administered s ubcutaneously 10 min prior to intraperitoneal injection of CCK (5 mcg/ kg) attenuated the suppressant effect of the peptide on feeding in a d ose-related manner Both doses of diazepam had no effect on food intake when administered alone. These results suggest that the benzodiazepin es interact with CCK by some unknown mechanism to modify feeding behav ior.