LINKAGE BETWEEN VITAMIN-D-BINDING PROTEIN AND ALPHA-FETOPROTEIN IN THE MOUSE

The albumin gene family consists of four evolutionarily related genes that code for serum transport proteins. In rodents, the genes for albu min, alpha-fetoprotein, and alpha ALB are physically linked within 100 kilobases of DNA. The fourth gene, Gc, encoding vitamin D-binding pro tein or group-specific component, maps to the same chromosome as the o ther family members, but linkage has not been established. This report describes the genetic and physical mapping of Ge in mouse and establi shes that, although Ge is genetically linked to the other genes, its p hysical distance from them extends beyond the resolution range of yeas t artificial chromosome cloning and pulsed-field gel electrophoresis.