AGE-RELATED MODIFICATIONS OF SOLUBLE-PROTEINS IN VARIOUS ORGANS OF MALE GARDEN LIZARD, CALOTES-VERSICOLOR

The oxidative modification of proteins measured as carbonyl derivative s increased with advancing age in the liver of male garden lizard. The same parameter did not show a significant change in other organs (bra in, heart and kidney). Based on the observations in both homeotherms ( mammals) and poikilotherms (insect and reptile), the in vivo oxidative modification of cellular proteins appears to be the most common mecha nism leading to accumulation of altered proteins during aging. However , the degree of modifications may vary among the tissues/organs of a s pecies. On the other hand the variations may also account for the role of modification of proteins in the pattern of aging in different spec ies.