EFFECT OF IVERMECTIN ON CAENORHABDITIS-ELEGANS LARVAE PREVIOUSLY EXPOSED TO ALCOHOLIC IMMOBILIZATION

First-stage larvae of Caenorhabditis elegans were immersed in 0.15% 1- phenoxy-2-propanol to induce temporary paralysis, including the suppre ssion of pharyngeal pumping. Subsequent addition of ivermectin (to giv e 50 mu g/ml) induced coiling and prolonged immobilization of such lar vae, as also of control larvae (previously immersed only in water). Th e results suggest that ingestion of drug by means of pharyngeal pumpin g is not a prerequisite for the uptake of ivermectin at levels suffici ent for antinematodal action.