ACETAZOLAMIDE PRODUCED BLOOD-FLOW VELOCITY CHANGES MEASURED BY LASER-DOPPLER IN GERBILS WITH REDUCED CBF

The effect of acetazolamide on the cerebral blood flow was studied in gerbils with unilateral carotid ligation. According to the effect of l igation the animals were divided into three groups: first group - the reduction more than 70%, second - CBF reduction 30-70% and the third g roup - CBF reduction less than 30%. The effect of acetazolamide admini stration was closely related to the effect of carotid ligation. More r eduction of CBF was produced by carotid ligation, less increase of CBF after acetazolamide injection was noticed. The acetazolamide vascular reserve test was found a sensitive and useful method for detecting ev en modest reduction of vascular reserve in animals with slight - less than 30% CBF decrease following carotid ligation.