To test the ability of a computer-based interview to detect factors re
lated to the risk of the human immunodeficiency virus (HIV) among pote
ntial blood donors, and to determine donor reactions to the use of the
computer, we compared the rate of detection of HIV-related factors el
icited by the computer interview with the rate elicited by standard Am
erican Red Cross procedures (written questionnaires and face-to-face i
nterviews) for assessment of donor suitability. The study was performe
d at a Red Cross blood donor center and a hospital. A consecutive samp
le of 294 male and female blood donors 18 to 75 years of age participa
ted in a randomized crossover trial in which the order of the two meth
ods was reversed. Among 272 prospective donors who provided complete d
ata, the computer identified 12 who reported either behavior associate
d with a risk of acquiring HIV or symptoms compatible with AIDS. None
of these 12 was so identified by face-to-face interviews or written qu
estionnaires. Only one used the confidential unit exclusion procedure
to prevent use of his donated blood. Tests for antibody to HIV were ne
gative in blood from all 272 subjects. The subjects enjoyed the comput
er interview and judged it to be more private than the standard method
for donor assessment.