To evaluate the structural changes in the carpal tunnel and possible i
ntrinsic median nerve damages in RA patients, quantitative bilateral m
agnetic resonance imaging (MRI) of the wrists was performed by means o
f a fast imaging sequence, Thirty-three women with Ri and 42 controls
were examined. The length of the carpal tunnel, the carpal tunnel volu
me/wrist volume (CTV/WV) ratio and the signal intensity of the nerve w
ere calculated in both groups, bilaterally, The CTV/WV ratio was 0.12
in the patients and 0.11 in the control group (p=0.007). A negative as
sociation was found between disease duration and carpal tunnel volume/
wrist volume ratio (p=0.049), Mean distal latency in the right motor m
edian nerve was 3.0+/-0.4 msec (patients) and 3.4+/-0.6 msec (controls
) (p=0.002). Mean values in the right sensory branch were 1.2+/-0.1 ms
ec (patients) and 1.4+/-0.3 (controls) (p=0.01), The lack of associati
on between the size of the carpal canal and neurophysiological paramet
ers found in this study may suggest a possible protection of the media
n nerve by the increased canal size in patients with RA.