SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (SICAM-1) IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS

Citation
N. Tulek et al., SOLUBLE INTERCELLULAR-ADHESION MOLECULE-1 (SICAM-1) IN PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS, Clinical rheumatology, 15(1), 1996, pp. 47-50
Citations number
24
Categorie Soggetti
Rheumatology
Journal title
ISSN journal
07703198
Volume
15
Issue
1
Year of publication
1996
Pages
47 - 50
Database
ISI
SICI code
0770-3198(1996)15:1<47:SIM(IP>2.0.ZU;2-F
Abstract
Circulating sICAM-1 is known to be elevated in various inflammatory di sorders. It is further suggested that elevated levels correlate well w ith disease activity in several autoimmune disorders. The objectives o f this study are to determine the serum sICAM-1 levels in patients wit h systemic lupus erythematosus (SLE) and correlate sICAM-1 levels with clinical and laboratory (ESR, CRP, anti-dsDNA) measures of disease ac tivity. Forty-one patients (34 female, 7 male) all fulfilling 1982 ARA classification criteria for SLE and 16 healthy controls (8 female, 8 male) were included in the study. Disease activity was measured accord ing to SLEDAI., sICAM-1 was determined by ELISA. Mean sICAM-1 in SLE p atients (349+/-161 ng/ml) were significantly higher than in the contro ls (216+/-85 ng/ml) (p < 0.005), Although slightly elevated in active patients, there was no statistically significant difference between me an sICAM-1 levels of active and inactive SLE patients (349+/-183 ng/ml and 316+/-103 ng/ml respectively) (p > 0.05). We could not find a cor relation between sICAM-1 levels and any organ involvements, Similarly, no significant correlation was found between ESR, CRP, anti-dsDNA and sICAM-1, These results suggest that although higher than normal, sICA M-1 levels in SLE do not provide additional information over conventio nal activity markers.