In the Literature many cases of Staphylococcus epidermidis (SE) compli
cations are reported, but we have not found any reference about reacti
ve arthritis secondary to SE. We report an unusual case of a patient w
ith SE bacteriaemia, who developed elbow arthritis, asymmetrical sacro
iliitis, keratoderma and restrictive cardiomyopathy. The clinical pict
ures, the instrumental and biochemical findings, in particular the pos
itivity of HLA B27, allow us to set this case in the complex and heter
ogeneous chapter of reactive arthritis.