Crystals of He-4 contain vacancies that move around by a quantum-mecha
nical hopping process. The density and pressure of these vacancies can
be experimentally studied. The accuracy of the experiments is high en
ough to detect the effect of the Bose statistics of the vacancies. In
this paper we examine the effect of the hard-core repulsion between th
e vacancies, which should also have a measurable effect on their behav
ior. We set up a virial expansion for a lattice gas of hard-core parti
cles, and calculate the second virial coefficient. It turns out that t
he vacancies behave as ideal Bose particles at low temperatures, but t
hat the hard-core interaction makes them behave more and more like fer
mions as the temperature increases.