CLINICAL AND IMMUNOLOGICAL CHARACTERISTICS OF THE EMULSION FORM OF INACTIVATED INFLUENZA VACCINE DELIVERED BY ORAL IMMUNIZATION

Prophylaxis of human respiratory diseases caused by influenza viruses is actually a problem of infectious pathology because of their wide pr evalence. In our investigations, safety, reactogenicity and immunologi cal activity of the orally administered emulsion-inactivated influenza vaccine prepared from influenza virus strains of types A(H1N1), A(H3N 2) and B have been studied. Clinical studies of the emulsion-inactivat ed influenza vaccine on volunteers has shown its safety and nonreactog enicity. The orally administered vaccine did not cause weak, middle or strong general or local reactions including clinical, biochemical, ha emotological and immunological reactions. The emulsion-inactivated vac cine has high immunological activity and induces reliable increases in the level of secretory immunoglobulin A to influenza viruses A and B in protective titers in nasal secretions and saliva of volunteers afte r one oral administration. The obtained results indicate the expedienc y of further investigation and improvement of inactivated influenza va ccine for oral administration.