DEVELOPMENT OF NOVEL VACCINES AGAINST ANTHRAX IN MAN

It has been shown that antianthrax immunity induced by the novel vacci ne proposed has not only antitoxic, but also antispore character. The whole complex of antigens, namely surface spore antigens, surface anti gens of cell wall and toxin components is required for the induction o f strong and stable immunity against anthrax. The STI-1 vaccine strain with introduced resistance to several antibiotics seems to be promisi ng for prophylaxis and treatment of anthrax in case of emergency, espe cially if antibiotic pretreatment could be expected. Tile technology f or submerged cultivation of Bacillus anthracis vaccine strain and for the development of an anthrax vaccine to be used in human medicine is proposed on the basis of the conception of the immunogenesis.