Pyoderma gangrenosum is well known as an associated feature of inflamm
atory bowel disease (IBD). Recently, higher than normal prevalence of
IBD in patients with the SAPHO (synovitis, acne, pustulosis, hyperosto
sis, osteitis) syndrome has been reported. However, the association of
pyoderma gangrenosum with SAPHO syndrome without definitely excluded
IBD has not been reported. We describe a case that suggests a possible
connection between these 2 entities.