Identical twins presented at the same time with renal failure, They al
so recalled a simultaneous history of ''nephritis'' as early as the ag
e of 6 years, Renal biopsies revealed variably thickened glomerular ba
sement membranes with the lamellation and splitting characteristic of
Alport's syndrome, Bilateral sensorineural deafness was demonstrated i
n both twins on audiometric testing, A positive family history in the
mother and one elder sister confirmed the diagnosis of Alport's syndro
me, This is the first reported case of Alport's syndrome occurring in
monozygotic twins. (C) 1996 by the National Kidney Foundation, Inc.