IN-VIVO BINDING OF LITHIUM USING THE CATION-EXCHANGE RESIN SODIUM POLYSTYRENE SULFONATE

The purpose of this study was to determine if the exchange resin sodiu m polystyrene sulfonate increases the clearance of lithium in a health y volunteer. A single healthy volunteer received 900 mg lithium for ea ch of three study phases, A sodium polystyrene sulfonate dose of eithe r 0, 20, or 40 grams was administered one half hour after each lithium dose to assess the effect on lithium clearance, Multiple blood sample s were obtained for serum lithium concentrations over a 36- to 48-hour time period, Pharmacokinetic parameter estimates were calculated and compared, Sodium polystyrene sulfonate was found to increase the clear ance of lithium in a single volunteer, Sodium polystyrene sulfonate ma y be useful in the treatment of lithium intoxication by increasing the clearance of lithium. (C) 1996 by W.B. Saunders Company