A 29-year-old male underwent allogeneic bone marrow transplantation fo
r progressive multiple myeloma. His post-transplant course was complic
ated by severe chronic pulmonary graft-versus-host disease (GVHD) resi
stant to cyclosporin A, corticosteroids and azathioprine. The introduc
tion of thalidomide resulted in a dramatic improvement in his lung fun
ction which has been maintained even after cessation of thalidomide. H
e remains well 40 months after transplantation.