MODIFYING TOXICOKINETICS WITH ANTIDOTES

Five approaches may be described through which antidotes can modify to xicokinetics: (1) Decreased bioavailability of the toxins; (2) Cellula r redistribution of the toxin in the organism; (3) Promotion of elimin ation in an unchanged form; (4) Slowing of metabolic activation pathwa ys; (5) Acceleration of metabolic deactivation pathways. However, the ability to modify toxicokinetics with a new treatment: while demonstra ting an understanding of the mechanism of action, must never be constr ued to be, in and of itself, the goal of therapy. The ultimate evaluat ion of an antidote modifying toxicokinetics is strictly clinical.