SOLID SUPPORT SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRAZOLES AND ISOXAZOLES - SCAFFOLDS FOR MOLECULAR DIVERSITY

Authors
MARZINZIK AL FELDER ER
Citation
Al. Marzinzik et Er. Felder, SOLID SUPPORT SYNTHESIS OF HIGHLY FUNCTIONALIZED PYRAZOLES AND ISOXAZOLES - SCAFFOLDS FOR MOLECULAR DIVERSITY, Tetrahedron letters, 37(7), 1996, pp. 1003-1006
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
7
Year of publication
1996
Pages
1003 - 1006
Database
ISI
SICI code
0040-4039(1996)37:7<1003:SSSOHF>2.0.ZU;2-H
Abstract
A scope and limitations study on a 4 steps reaction sequence including a Claisen condensation, an alpha-alkylation, and a cyclization of a b eta-diketone with monosubstituted hydrazines for the generation of var iably substituted pyrazoles and isoxazoles on solid phase is described . The ample choice of reactants compatible with the reaction scheme po ints out its potential in combinatorial chemistry.