SYNTHESIS OF PYRROLIDINE-2,4-DIONES FROM URETHANE N-CARBOXYANHYDRIDES(UNCAS)

Authors
POTHION C FEHRENTZ JA AUMELAS A LOFFET A MARTINEZ J
Citation
C. Pothion et al., SYNTHESIS OF PYRROLIDINE-2,4-DIONES FROM URETHANE N-CARBOXYANHYDRIDES(UNCAS), Tetrahedron letters, 37(7), 1996, pp. 1027-1030
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
7
Year of publication
1996
Pages
1027 - 1030
Database
ISI
SICI code
0040-4039(1996)37:7<1027:SOPFUN>2.0.ZU;2-C
Abstract
In the presence of a base in aprotic medium, UNCAs lead to N-urethane protected-3,5-dialkyl-3-amino pyrrolidine-2,4-diones as racemic cis/tr ans mixtures. Consequently the choice of the base should be carefully considered to optimize yields and avoid side products when UNCAs are u sed in peptide synthesis.