A CONVENIENT SYNTHESIS OF 1-ETHOXYMETHYL-5-NITRO-6-SUBSTITUTED URACILS

Authors
BENHIDA R AUBERTIN AM GRIERSON DS MONNERET C
Citation
R. Benhida et al., A CONVENIENT SYNTHESIS OF 1-ETHOXYMETHYL-5-NITRO-6-SUBSTITUTED URACILS, Tetrahedron letters, 37(7), 1996, pp. 1031-1034
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
7
Year of publication
1996
Pages
1031 - 1034
Database
ISI
SICI code
0040-4039(1996)37:7<1031:ACSO1U>2.0.ZU;2-A
Abstract
Two new and versatile synthetic methods for preparing 5-nitro-analogue s of HEPT and MKC-442 which are HIV-1 reverse transcriptase inhibitors , are reported. In both cases the key-step is based upon the displacem ent of a 6-methylthio or a 6-tosyl group by nucleophiles according an addition-elimination type mechanism.