H. Shiragami et al., SYNTHESIS OF 2',3'-DIDEOXYPURINENUCLEOSIDES VIA THE PALLADIUM-CATALYZED REDUCTION OF ACETYL-3-BROMO-3-DEOXY-BETA-D-XYLOFURANOSYL)PURINE DERIVATIVES, Nucleosides & nucleotides, 15(1-3), 1996, pp. 31-45
Practical method to produce 2',3'-dideoxypurinenucleosides from cetyl-
3-bromo-3-deoxy-beta-D-xylofuranosyl)purines (1) was developed. High r
atio of 2',3 '-dideoxynucleoside to 3'-deoxyribonucleoside was obtaine
d by Selecting the reaction conditions (solvent, pH and/or base), or c
hanging 2'-acyloxy leaving group. The reaction mechanism was studied b
y deuteration experiments of 1a and cetyl-2-bromo-2-deoxy-beta-D-ribof
uranosyl)thymine (12).