NUCLEOSIDES AND NUCLEOTIDES .140. SYNTHESIS AND ANTILEUKEMIC ACTIVITYOF 5-CARBON-SUBSTITUTED 1-BETA-D-RIBOFURANOSYLIMIDAZOLE-4-CARBOXAMIDES

Authors
MINAKAWA N KOJIMA N SASAKI T MATSUDA A
Citation
N. Minakawa et al., NUCLEOSIDES AND NUCLEOTIDES .140. SYNTHESIS AND ANTILEUKEMIC ACTIVITYOF 5-CARBON-SUBSTITUTED 1-BETA-D-RIBOFURANOSYLIMIDAZOLE-4-CARBOXAMIDES, Nucleosides & nucleotides, 15(1-3), 1996, pp. 251-263
Citations number
21
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
1-3
Year of publication
1996
Pages
251 - 263
Database
ISI
SICI code
0732-8311(1996)15:1-3<251:NAN.SA>2.0.ZU;2-D
Abstract
Synthesis of 5-carbon-substituted 1-beta-D-ribofuranosylimidazole-4-ca rboxamides are described. Treatment of 5-iodo derivative 8 with methyl acrylate in the presence of palladium catalyst gave (E)-5-(2-carbomet hoxyvinyl)-1-(2,3,5-tri-O-acetyl- beta-D-ribofuranosyl)imidazole-4-car boxamide (9), followed by appropriate manipulations to afford various 5-carbon-substituted imidazole derivatives 1-7. The antileukemic activ ities of these imidazole nucleosides are also described.