NUCLEOSIDES .58. SYNTHESIS OF BASE - MODIFIED OLIGONUCLEOTIDES CONTAINING 6-ARYL AND 7-ARYL LUMAZINES

Authors
MAURINSH Y PFLEIDERER W
Citation
Y. Maurinsh et W. Pfleiderer, NUCLEOSIDES .58. SYNTHESIS OF BASE - MODIFIED OLIGONUCLEOTIDES CONTAINING 6-ARYL AND 7-ARYL LUMAZINES, Nucleosides & nucleotides, 15(1-3), 1996, pp. 431-443
Citations number
23
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
1-3
Year of publication
1996
Pages
431 - 443
Database
ISI
SICI code
0732-8311(1996)15:1-3<431:N.SOB->2.0.ZU;2-K
Abstract
6-Phenyl-, 7-phenyl-, 6-(4-biphenyl)-7-(4-biphenyl)lumazine N-1-2-deox y-beta-D-ribofuranosides were synthesized, then converted into the cor responding 5'-O-dimethoxytrityl-3'-O-(beta-cyanoethyl, N,N-diisopropyl )phosphoramidites and incorporated into different positions of self-co mplementary oligonucleotides. The influence of modifications on the me lting temperature of the resulting duplexes was studied.