BIOLOGICALLY-ACTIVE OLIGODEOXYRIBONUCLEOTIDES .4. ANTI-HIV-1 ACTIVITYOF TGGGAG HAVING HYDROPHOBIC SUBSTITUENT AT ITS 5'-END VIA PHOSPHODIESTER LINKAGE

Authors
HOTODA H KOIZUMI M KOGA R MOMOTA K OHMINE T FURUKAWA H NISHIGAKI T KINOSHITA T KANEKO M KIMURA S SHIMADA K
Citation
H. Hotoda et al., BIOLOGICALLY-ACTIVE OLIGODEOXYRIBONUCLEOTIDES .4. ANTI-HIV-1 ACTIVITYOF TGGGAG HAVING HYDROPHOBIC SUBSTITUENT AT ITS 5'-END VIA PHOSPHODIESTER LINKAGE, Nucleosides & nucleotides, 15(1-3), 1996, pp. 531-538
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
15
Issue
1-3
Year of publication
1996
Pages
531 - 538
Database
ISI
SICI code
0732-8311(1996)15:1-3<531:BO.AA>2.0.ZU;2-K
Abstract
Hexadeoxyribonucleotides (6-mers) having a 5'-TGGGAG-3' sequence beari ng hydrophobic substituents at their 5'-ends via phosphodiester linkag es were prepared and evaluated for anti-HTV-1 activity in vitro. Some of these modified 6-mers showed weak anti-HIV-1 activities and they we re less potent than the 6-mer having a DMTr group directly attached at its 5'-terminus.